Bisphosphonates are a group of drugs that inhibit bone resorption and consequently increase cortical and trabecular bone volume. Furthermore, they are not metabolized and therefore remain in the bone at high concentrations for extended periods. They are used in the treatment of osteoporosis in menopause, Paget's disease, osteolytic lesions from bone metastases, hyperthyroidism, and during prolonged corticosteroid therapy.

In recent years, cases of osteonecrosis of the jaws have appeared, a pathology consisting of partial and localized loss of bone tissue, with or without pain, often in an area where an extraction or surgery has occurred that has resulted in the exposure of the bone.

Osteonecrosis from bisphosphonates has occurred predominantly in cases of prolonged and intravenous treatment, but it cannot be ruled out with other types of administration. It is therefore very important to inform the person prescribing bisphosphonates about your oral health, as well as your dentist, that you are undergoing treatment with these drugs. Furthermore, before starting treatment with bisphosphonates, it is important to have a check-up with your dentist and a professional oral hygiene session, as well as schedule any extractions or implant surgery before starting treatment.